Sylvia Mark is one in a hundred. But considering who those hundred are, that makes her far more special than your run-of-the-mill one in a million. Plagued with dreams she can't understand, the moody adopted teenager suddenly finds herself more of an outcast than ever when she begins exhibiting supernormal levels of agility and strength.
Overhearing her mother's distress about Sylvia's recent behavior, and (correctly) sensing regret over taking her in, Sylvia packs up and hits the road which is where she quickly meets up with Regina... who looks exactly like Sylvia, but without the strength and agility. Regina's talent is that she can sense the location of the rest of her sisters the remaining 98 of them. But before she can fully explain what that means to Sylvia, the girls are beset by men in black who exhibit comic book super powers of their own, as well as a determination to capture the girls if possible.
As Sylvia and Regina go on the run, Sylvia learns she has another, more gruesome ability that takes the tale to a whole different level as Sylvia's power levels continue to grow with each new encounter.
Adam Gallardo weaves an intriguing, engrossing story that mixes superheroics and super-science with mundane sensibilities, creating a story that's approachable and enjoyable even by those who don't like the tights-and-cape crowd. 100 Girls runs more along the lines of Heroes and The 4400, with more than a dash of "Anna to the Infinite Power." Todd Demong's artwork is dynamic and expressive, but tends to get a tad over-exaggerated on the adult faces the males lean toward having elongated nostrums (that distance between your nose and your upper lip), while the female Dr. Carver looks perpetually tired and haggard, making her sexual appeal to some of her male companions questionable, at least to this reader.
Everything builds to a conclusion that is both satisfying, exciting, and... well... "conclusive" but with an obvious opening for further adventure (that whole "End of Book One" on the last page being the most obvious clue). It's enjoyable on its own, eschewing some lame cliffhanger ending to make you think you have to have the next book. Instead, you'll want the next book because you'll be interested in seeing more of the characters and where they're going to go from here. I know that's what's going to bring me back for more.